Wycillin

Generic Name: procaine penicillin (PRO kane PEN i SIL in)

Brand Names: Wycillin

What is procaine penicillin ?

Procaine penicillin is an antibiotic that fights bacteria in your body.

Procaine penicillin is used to treat many different types of infections caused by bacteria, including syphilis (a sexually transmitted disease).

Do not use this medication for any other infection that has not been checked by your doctor.

Procaine penicillin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about procaine penicillin ?

You should not use this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as Ceftin, Cefzil, Omnicef, Keflex, and others.

Before using procaine penicillin, tell your doctor if you have asthma or a history of allergies, or kidney disease.

Do not inject this medication into a vein or life-threatening side effects may result.

Use this medication for the full prescribed length of time. Call your doctor if your infection does not improve, or if it gets worse while using procaine penicillin.

Tell your doctor about all other medications you use, especially gout medication, a blood thinner, a diuretic, a tetracycline antibiotic, or a non-steroidal anti-inflammatory drug (NSAID).

Procaine penicillin can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using procaine penicillin. Hormonal forms of contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

After you have finished your treatment with procaine penicillin, your doctor may want to do tests to make sure your infection has completely cleared up.

What should I discuss with my health care provider before using procaine penicillin ?

You should not use this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as Ceclor, Ceftin, Duricef, Keflex, Lorabid, Omnicef, Spectracef, and others.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use procaine penicillin:

• 
  

  asthma or a history of allergies; or

  
  


• kidney disease.

FDA pregnancy category B. Procaine penicillin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Procaine penicillin can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using procaine penicillin. Hormonal forms of contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Procaine penicillin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Wycillin (procaine penicillin)?

Procaine penicillin is given as an injection into a muscle. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Procaine penicillin must be injected slowly into a muscle of the buttock or upper thigh.

Do not inject the medication into a vein or life-threatening side effects could result.

Your procaine penicillin injections should be given at evenly spaced intervals.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Procaine penicillin will not treat a viral infection such as the common cold or flu.

Call your doctor if your infection does not improve, or if it gets worse while using procaine penicillin.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

This medication can cause you to have unusual results with certain lab tests, including tests to check for glucose (sugar) in the urine. Tell any doctor who treats you that you are using procaine penicillin.

After you have finished your treatment with procaine penicillin, your doctor may want to do tests to make sure your infection has completely cleared up.

Store this medication in the refrigerator. Do not freeze. Do not use the mixed medication if it has changed colors or has any particles in it.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include mood changes, agitation, confusion, and seizure (convulsions).

What should I avoid while using Wycillin (procaine penicillin)?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop using this medication and call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Do not receive a "live" vaccine such as typhoid vaccine, cholera vaccine, or BCG (Bacillus Calmette and Guérin) vaccine.

Procaine penicillin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  diarrhea that is watery or bloody;

  
  


• 
  

  peeling skin , severe pain, or changes in skin color where the medicine was injected;

  
  


• 
  

  dizziness, joint or muscle pain;

  
  


• 
  

  fast or pounding heartbeats;

  
  


• 
  

  numbness, tingling, pain, swelling, or redness in your arms or legs;

  
  


• 
  

  confusion, agitation, depression, unusual thoughts or behavior;

  
  


• 
  

  chest pain, problems with vision or speech;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  fever, chills, dizziness, muscle pain, rapid breathing or heart rate;

  
  


• 
  

  uncontrolled muscle movements, problems with balance or walking;

  
  


• 
  

  pale skin, easy bruising or bleeding, unusual weakness;

  
  


• 
  

  sore throat, flu symptoms;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  rash or itching with swollen glands, joint pain, or general ill feeling; or

  
  


• 
  

  slow heart rate, weak pulse, fainting, slow breathing.

  
  

Less serious side effects may include:

• 
  

  pain where the injection was given;

  
  


• 
  

  vaginal itching or discharge;

  
  


• 
  

  white patches in your mouth or throat;

  
  


• 
  

  nausea, vomiting;

  
  


• 
  

  blurred vision, ringing in your ears;

  
  


• 
  

  headache, dizziness; or

  
  


• 
  

  mild skin rash,

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Wycillin (procaine penicillin)?

Tell your doctor about all other medications you use, especially:

• 
  

  probenecid (Benemid);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  a diuretic (water pill) such as furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor HCT, Vasoretic, Zestoretic), and others;

  
  


• 
  

  methotrexate (Rheumatrex, Trexall);

  
  


• 
  

  a tetracycline antibiotic, such as demeclocycline (Declomycin, Ledermycin), doxycycline (Adoxa, Doryx, Vibramycin, Periostat), minocycline (Minocin), or tetracycline (Broadspec, Panmycin, Sumycin); or

  
  


• 
  

  NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), naproxen (Aleve, Naprosyn), meloxicam (Mobic), piroxicam (Feldene), and others.

  
  

This list is not complete and there may be other drugs that can interact with procaine penicillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Wycillin resources

• Wycillin Side Effects (in more detail)
• Wycillin Use in Pregnancy & Breastfeeding
• Wycillin Drug Interactions
• Wycillin Support Group
• 0 Reviews for Wycillin - Add your own review/rating

Compare Wycillin with other medications

• Anthrax Prophylaxis
• Bacterial Infection
• Congenital Syphilis
• Cutaneous Bacillus anthracis
• Diphtheria
• Endocarditis
• Fusospirochetosis, Trench Mouth
• Neurosyphilis
• Pneumonia
• Rat-bite Fever
• Skin Infection
• Streptococcal Infection
• Syphilis, Early
• Syphilis, Latent
• Tertiary Syphilis
• Tonsillitis/Pharyngitis
• Upper Respiratory Tract Infection

Where can I get more information?

• Your doctor or pharmacist can provide more information about procaine penicillin.

See also: Wycillin side effects (in more detail)

Wellbutrin XL Extended-Release Tablets

Pronunciation: bue-PROE-pee-on
Generic Name: Bupropion
Brand Name: Wellbutrin XL

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Wellbutrin XL Extended-Release Tablets outweigh the risks.

Wellbutrin XL Extended-Release Tablets has the same ingredient in it that is in Zyban, a medicine used to help certain patients stop smoking. Some patients using bupropion to help them stop smoking have also developed depression and certain other mental or mood problems, including suicidal thoughts or actions.

Family and caregivers must closely watch patients who take Wellbutrin XL Extended-Release Tablets. It is important to keep in close contact with the patient's doctor. Contact the doctor at once if new, worsened, or sudden symptoms such as agitation, hostility, depressed mood, or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur. Discuss any questions with the patient's doctor.

Wellbutrin XL Extended-Release Tablets are used for:

Treating depression and seasonal affective disorder (SAD). It may also be used for other conditions as determined by your doctor.

Wellbutrin XL Extended-Release Tablets are an antidepressant. It works in the brain to treat depression. Exactly how it works is not known.

Do NOT use Wellbutrin XL Extended-Release Tablets if:

• you are allergic to any ingredient in Wellbutrin XL Extended-Release Tablets


• you are taking any other medicine that contains bupropion


• you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy)


• you are suddenly stopping the use of alcohol or sedatives (eg, benzodiazepines) after long-term use


• you are taking or have taken linezolid, methylene blue, or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Wellbutrin XL Extended-Release Tablets:

Some medical conditions may interact with Wellbutrin XL Extended-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse


• if you have diabetes, kidney problems, liver problems (eg, cirrhosis), high blood pressure, heart problems (eg, congestive heart failure), or a recent heart attack


• if you have a history of seizures, a head injury, or a tumor in the brain or spinal cord


• if you are taking nonprescription weight loss medicines or stimulants

Some MEDICINES MAY INTERACT with Wellbutrin XL Extended-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, other antidepressants (eg, amitriptyline, fluvoxamine), antipsychotics (eg, haloperidol, risperidone), clopidogrel, corticosteroids (eg, prednisone), cyclophosphamide, HIV protease inhibitors (eg, nelfinavir), insulin, levodopa, linezolid, MAOIs (eg, phenelzine), methylene blue, nicotine patches, oral hypoglycemics (eg, glipizide), orphenadrine, sympathomimetics (eg, pseudoephedrine), theophylline, thiotepa, tiagabine, or ticlopidine because they may increase the risk of Wellbutrin XL Extended-Release Tablets's side effects


• Carbamazepine, efavirenz, phenobarbital, phenytoin, rifampin, or ritonavir because they may decrease Wellbutrin XL Extended-Release Tablets's effectiveness


• Antiarrhythmics (eg, flecainide, propafenone), beta-blockers (eg, metoprolol), phenothiazines (eg, thioridazine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or tricyclic antidepressants (eg, nortriptyline) because the risk of their side effects may be increased by Wellbutrin XL Extended-Release Tablets


• Tamoxifen because its effectiveness may be decreased by Wellbutrin XL Extended-Release Tablets, which may lead to an increased risk of breast cancer recurrence in women with a history of breast cancer

This may not be a complete list of all interactions that may occur. Ask your health care provider if Wellbutrin XL Extended-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Wellbutrin XL Extended-Release Tablets:

Use Wellbutrin XL Extended-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wellbutrin XL Extended-Release Tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Wellbutrin XL Extended-Release Tablets refilled.


• Take Wellbutrin XL Extended-Release Tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Swallow Wellbutrin XL Extended-Release Tablets whole. Do not break, crush, divide, or chew before swallowing.


• Several weeks may pass before your symptoms get better. Do not stop taking Wellbutrin XL Extended-Release Tablets without checking with your doctor.


• Take your doses at the same time each day, at least 24 hours apart. This may help to decrease the risk of seizures with Wellbutrin XL Extended-Release Tablets.


• Continue to take Wellbutrin XL Extended-Release Tablets even if you feel well. Do not miss any doses.


• If you miss a dose of Wellbutrin XL Extended-Release Tablets, skip the missed dose and go back to your regular dosing schedule. Do not take more than 1 dose within 24 hours. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Wellbutrin XL Extended-Release Tablets.

Important safety information:

• Wellbutrin XL Extended-Release Tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Wellbutrin XL Extended-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Wellbutrin XL Extended-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Wellbutrin XL Extended-Release Tablets may increase your risk of seizures. Your risk may be greater if you also have certain medical conditions, use certain medicines, or if you use a lot of alcohol. Talk to your doctor to see if you may have a greater risk of seizures while taking Wellbutrin XL Extended-Release Tablets.


• If you already drink alcohol or use sedatives, do not suddenly stop them without first checking with your doctor. Suddenly stopping them may increase your seizure risk.


• Do not take decongestants (eg, pseudoephedrine), stimulants, or diet pills while you are taking Wellbutrin XL Extended-Release Tablets without first checking with your doctor. They may increase your risk of seizures.


• The risk of seizures may be greater if you take Wellbutrin XL Extended-Release Tablets in high doses or for a long time. Do NOT take more than the recommended dose, change your dose, or use Wellbutrin XL Extended-Release Tablets for longer than prescribed without checking with your doctor.


• Children, teenagers, and young adults who take Wellbutrin XL Extended-Release Tablets may be at increased risk for suicidal thoughts or actions. Watch all patients who take Wellbutrin XL Extended-Release Tablets closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• You may notice the tablet shell in your stool. This is normal and not a cause for concern.


• If you have trouble sleeping, you may be taking your dose too close to bedtime. Talk with your doctor about changing your dosing schedule.


• Wellbutrin XL Extended-Release Tablets has the same ingredients in it as Zyban, a medicine used to help stop smoking, and Aplenzin, another medicine used to treat depression. Do not take Wellbutrin XL Extended-Release Tablets if you are also taking Zyban or Aplenzin . Discuss any questions or concerns with your doctor.


• Wellbutrin XL Extended-Release Tablets may interfere with certain lab tests, including urine screenings for amphetamines. Be sure your doctor and lab personnel know you are taking Wellbutrin XL Extended-Release Tablets.


• Use Wellbutrin XL Extended-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.


• Wellbutrin XL Extended-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Wellbutrin XL Extended-Release Tablets while you are pregnant. Wellbutrin XL Extended-Release Tablets are found in breast milk. Do not breast-feed while taking Wellbutrin XL Extended-Release Tablets.

Possible side effects of Wellbutrin XL Extended-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth; flushing; gas; headache; increased sweating; increased urination; loss of appetite; nausea; nervousness; restlessness; ringing in the ears; stomach pain; taste changes; trouble sleeping; vomiting; weakness; weight changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue, unusual hoarseness); chest pain; confusion; dark urine; delusions; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; hearing problems or ringing in the ears; menstrual changes; new or worsening mental or mood changes (eg, concentration problems, depression, panic attacks, aggressiveness, agitation, anxiety, impulsiveness, irritability, hostility, exaggerated feeling of well-being, inability to sit still); pale stools; red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent joint or muscle pain; severe or persistent nausea, vomiting, or stomach pain; severe or persistent nervousness, restlessness, or trouble sleeping; shortness of breath; suicidal thoughts or attempts; tremor; unusual swelling; vision changes; worsening depression; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Wellbutrin XL side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; loss of consciousness; rigid or painful muscles; seizures; severe dizziness; slow or difficult breathing.

Proper storage of Wellbutrin XL Extended-Release Tablets:

Store Wellbutrin XL Extended-Release Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Wellbutrin XL Extended-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Wellbutrin XL Extended-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Wellbutrin XL Extended-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Wellbutrin XL Extended-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Wellbutrin XL resources

• Wellbutrin XL Side Effects (in more detail)
• Wellbutrin XL Dosage
• Wellbutrin XL Use in Pregnancy & Breastfeeding
• Drug Images
• Wellbutrin XL Drug Interactions
• Wellbutrin XL Support Group
• 68 Reviews for Wellbutrin XL - Add your own review/rating

Compare Wellbutrin XL with other medications

• Depression
• Seasonal Affective Disorder

WelChol

Generic Name: Colesevelam Hydrochloride
Class: Bile Acid Sequestrants
VA Class: CV350
Chemical Name: 2-Propen-1-amine polymer withN,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride-(chloromethyl)oxirane and N-2-propenyl-1-decanamine hydrochloride
Molecular Formula: (C₃H₇N)_m(C₃H₅ClO)_n(C₁₂H₂₇ClN₂)_o(C₁₃H₂₇N)_p•_xHCl
CAS Number: 182815-44-7

Introduction

Antilipemic agent (bile acid sequestrant).¹ Adjunct antidiabetic agent for type 2 diabetes mellitus.¹

Uses for WelChol

Primary Hypercholesterolemia

Adjunct to dietary therapy and exercise to decrease elevated serum LDL-cholesterol concentrations in the management of primary hypercholesterolemia (Frederickson type IIa).^{1 2 3 5 6}

May be used alone or combined with a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (i.e., statin).¹

Effect of colesevelam (alone or in combination with a statin on cardiovascular morbidity and mortality not established.^{1 2}

Safety and efficacy of colesevelam for management of Fredrickson type I, III, IV, and V dyslipidemias† not established.¹

Diabetes Mellitus

Used in combination with metformin, sulfonylurea, or insulin monotherapy or in combinations with these and other oral antidiabetic agents as an adjunct to diet and exercise for the management of type 2 diabetes mellitus.^{1 13}

Safety and efficacy as monotherapy or in combination with a dipeptidyl peptidase-4 (DPP-4) inhibitor not established in type 2 diabetes mellitus; has not been studied extensively in combination with thiazolidinediones.¹

Not effective as sole therapy for type 1 diabetes mellitus or diabetic ketoacidosis.¹

WelChol Dosage and Administration

General

• 
  

  Institute standard lipid-lowering diet before initiation of colesevelam therapy; patient should remain on this diet during treatment with the drug.^{1 7 8 10}

  
  

Monitoring during Antilipemic Therapy

• 
  

  Monitor serum lipoprotein concentrations periodically (initially, within 4–6 weeks after treatment initiation) to ensure that target LDL-cholesterol goals are achieved and maintained at <100 mg/dL (optional goal: <70 mg/dL) for patients with CHD or CHD risk equivalents; <130 mg/dL (optional goal: <100 mg/dL) for patients with ≥2 risk factors and 10-year risk of 10–20%; <130 mg/dL for patients with ≥2 risk factors and 10-year risk <10%; or <160 mg/dL for patients with 0–1 risk factor.^{1 15} In those with serum triglyceride concentrations exceeding 200 mg/dL, non-HDL-cholesterol (calculated as total cholesterol minus HDL-cholesterol) becomes a secondary target of therapy.^{1 8 10} The target non-HDL-cholesterol concentration in patients with high serum triglyceride concentrations is 30 mg/dL higher than the target LDL-cholesterol concentration.^{1 15}

  
  

  Intensive control of hyperlipidemia warranted in addition to glycemic control in patients with diabetes mellitus.¹

  
  

Administration

Oral Administration

Administer orally once or twice daily with a liquid at mealtime.^{1 2}

May be administered simultaneously with a statin.¹

Drugs known to interact with colesevelam or drugs that have not been evaluated in formal drug interaction studies with colesevelam, especially those with a narrow therapeutic index, (see Interactions), should be administered at least 4 hours prior to colesevelam.¹ Alternatively, monitor blood concentrations of the co-administered drug.¹

Dosage

Available as colesevelam hydrochloride; dosage expressed in terms of colesevelam.¹

Adults

Dyslipidemias

Primary Hypercholesterolemia

Oral

Initially, 1.875 g (3 tablets) twice daily or 3.75 g (6 tablets) once daily.^{1 2} May increase dosage to 4.375 g (7 tablets) daily depending on desired therapeutic effect.¹

Diabetes Mellitus

Oral: 1.875 g (3 tablets) twice daily or 3.75 g (6 tablets) once daily in combination with other antidiabetic agents (e.g., metformin, a sulfonylurea, insulin) in patients with type 2 diabetes mellitus.^{1 9}

Therapeutic response usually occurs following 4–6 weeks of treatment and reaches maximal or near maximal after 12–18 weeks of therapy.^{1 13}

Cautions for WelChol

Contraindications

• 
  

  Bowel obstruction.¹

  
  


• 
  

  Serum triglyceride concentrations exceeding 500 mg/dL.^{1 12}

  
  


• 
  

  History of hypertriglyceridemia-induced pancreatitis.^{1 12}

  
  


• 
  

  Known hypersensitivity to colesevelam or any ingredient in the formulation.¹

  
  

Warnings/Precautions

General Precautions

Hypertriglyceridemia

Increased serum triglyceride concentrations reported in patients with primary hypercholesterolemia or type 2 diabetes mellitus who were treated with colesevelam.^{1 13} Colesevelam may increase serum triglycerides, particularly in patients receiving concomitant insulin or sulfonylurea therapy.^{1 13}

Not systematically studied in patients with triglyceride concentrations >300 mg/dL.¹ Use caution in such patients because bile acid sequestrants may increase triglyceride concentrations.¹

Severe hypertriglyceridemia can cause pancreatitis.¹ Discontinue therapy if serum triglyceride concentrations exceed 500 mg/dL or hypertriglyceridemia-induced pancreatitis occurs.¹

Fat-soluble Vitamin Deficiency

Bile acid sequestrants may decrease absorption of fat-soluble vitamins A, D, E, and K.¹ Effects of colesevelam on co-administered dietary or supplemental vitamin therapy, including such use in pregnant women, not established.¹

Hemorrhage from vitamin K deficiency reported in rats receiving relatively high doses (30 times the usual human dosage).¹ Clinically important effects on absorption of fat-soluble vitamins not observed in clinical trials.^{1 2 3} Use caution in patients susceptible to vitamin K deficiency (e.g., concomitant warfarin therapy, malabsorption syndromes) or other fat-soluble vitamin deficiency.¹ (See Interactions.)

GI Disorders

Large tablet size of colesevelam may cause dysphagia or esophageal obstruction; use caution in patients with dysphagia or swallowing disorders.¹

Not recommended in patients with gastroparesis, other GI motility disorders, or those who have undergone major GI tract surgery and who may be at risk for bowel obstruction.¹

Combination Therapy

When used in combination with metformin, a sulfonylurea, or insulin, consider the cautions, precautions, and contraindications associated with the concomitant agent(s).¹

Specific Populations

Pregnancy

Category B.¹

Requirements for vitamins and other nutrients increased during pregnancy.¹ (See Fat-soluble Vitamin Deficiency under Cautions.)

Lactation

Colesevelam is not expected to distribute into milk.⁹

Pediatric Use

Safety and efficacy not established in children <18 years of age.^{1 9} Not recommended in pediatric patients because of large tablet size.¹

Geriatric Use

No overall differences in safety and efficacy relative to younger adults, but increased sensitivity cannot be ruled out.¹

Renal Impairment

In patients with type 2 diabetes mellitus, no overall differences in safety or efficacy observed between patients with moderate renal insufficiency (Cl_cr <50 mL/minute) and those with mild renal insufficiency (Cl_cr ≥50 mL/minute).¹

Common Adverse Effects

Patients with primary hypercholesterolemia: Constipation,^{1 2 3 5} dyspepsia,^{1 2 3 5} nausea,^{1 3 5} accidental injury,^{1 5} asthenia,¹ pharyngitis,^{1 5} flu-like syndrome,^{1 5} rhinitis,^{1 5} myalgia.^{1 2 5}

Patients with type 2 diabetes mellitus: Constipation,^{1 13} nasopharyngitis,^{1 13} dyspepsia,¹ hypoglycemia,^{1 13} nausea,^{1 13} hypertension.^{1 13}

Interactions for WelChol

If administered with a drug with a narrow therapeutic index (i.e., alterations in blood concentrations associated with clinically important effect on efficacy and/or safety) that has not been evaluated in formal drug interaction studies, administer drug at least 4 hours prior to colesevelam, or consider monitoring drug concentrations.¹

Increased serum triglyceride concentrations observed in clinical studies with concomitant sulfonylurea or insulin therapy.^{1 13}

Specific Drugs

Drug	Interaction	Comments
Cephalexin	Pharmacokinetic interaction unlikely1
Ciprofloxacin	Pharmacokinetic interaction unlikely1
Digoxin	Pharmacokinetic interaction unlikely1
Fat-soluble vitamins (i.e., vitamins A, D, E, K)	Potential decreased absorption of fat-soluble vitamins A, D, E, K1 (see Fat-soluble Vitamin Deficiency under Cautions)	Administer at least 4 hours prior to colesevelam1
Fenofibrate	Additive effects in reducing total and LDL cholesterol1
HMG-CoA reductase inhibitors (statins)	Additive antilipemic effects1 2 5 Lovastatin: Pharmacokinetic interaction unlikely1	Used to therapeutic advantage1
Glyburide	Potential decreased peak plasma concentration and AUC of glyburide1	Administer at least 4 hours prior to colesevelam1
Metoprolol	Pharmacokinetic interaction unlikely1
Quinidine	Pharmacokinetic interaction unlikely1
Oral contraceptives (ethinyl estradiol combined with norethindrone)	Decreased peak blood concentrations of ethinyl estradiol and norethindrone, decreased AUC of ethinyl estradiol1	Administer at least 4 hours prior to colesevelam1
Phenytoin	Potential decreased blood phenytoin concentrations; potential for increased seizure activity1	Administer at least 4 hours prior to colesevelam1
Thyroid agents (e.g., levothyroxine)	Increased TSH concentrations; decreased peak blood levothyroxine concentrations and AUC1	Administer at least 4 hours prior to colesevelam1
Valproic acid	Pharmacokinetic interaction unlikely1
Verapamil (extended-release)	Pharmacokinetic interaction unlikely1
Warfarin	Potential reduced INR; pharmacokinetic interaction unlikely1	Monitor INR prior to colesevelam therapy and subsequently to ensure no appreciable alteration in INR; once INR is stable, monitor periodically at recommended intervals for warfarin therapy1

WelChol Pharmacokinetics

Absorption

Bioavailability

Not absorbed from the GI tract.^{1 2 4 5}

Onset

Maximum therapeutic response usually occurs within 2 weeks and is maintained during long-term (≥50 weeks) therapy.^{1 2 3 9}

Elimination

Elimination Route

Binds to bile acids in the intestine and forms a nonabsorbable complex that is excreted in feces.^{1 2 3 4}

Stability

Storage

Oral

Tablets

25°C (may be exposed to 15–30°C).¹ Protect from moisture.¹

ActionsActions

• 
  

  Binds to bile acids in the intestine and forms a nonabsorbable complex.^{1 2 3 4} Partial removal of bile acids from enterohepatic circulation results in increased conversion of cholesterol to bile acids in the liver.^{1 2 4 5} This causes an increased demand for cholesterol in liver cells, resulting in a compensatory increase in hepatic uptake (and thus systemic clearance) of circulating LDL-cholesterol.^{1 2}

  
  


• 
  

  Reduces serum total cholesterol, LDL-cholesterol, and apolipoprotein B (apo B), and increases HDL-cholesterol concentrations.^{1 2 3 4 5} Serum triglyceride concentrations may remain unchanged or increase slightly (5–10%).^{1 3 5 6}

  
  

  The mechanism by which colesevelam improves glycemic control is unknown.^{1 14}

  
  

Advice to Patients

• 
  

  Risk of increased serum triglyceride concentrations in diabetic patients receiving colesevelam with a sulfonylurea or insulin; long-term effect of hypertriglyceridemia on CAD risk uncertain.¹

  
  


• 
  

  Importance of informing a clinician of high triglyceride concentrations (i.e., >300 mg/dL) before starting colesevelam therapy.^{1 12}

  
  


• 
  

  Importance of adherence to prescribed directions for use.¹

  
  


• 
  

  Importance of taking certain other drugs (e.g., glyburide, thyroid agents, oral contraceptives, warfarin, phenytoin, fat-soluble vitamins) at least 4 hours before colesevelam.¹

  
  


• 
  

  Importance of adhering to nondrug therapies and measures (i.e., therapeutic lifestyle changes, including dietary management, weight control, physical activity, and management of potentially contributory disease [e.g., diabetes mellitus]).¹

  
  


• 
  

  Importance of instructing diabetic patients regarding self-monitoring of blood glucose, adherence to meal planning, and regular physical exercise.¹

  
  


• 
  

  Importance of discontinuing colesevelam and seeking medical advice if severe abdominal pain or severe constipation occurs.¹

  
  


• 
  

  Importance of discontinuing colesevelam and seeking medical advice if symptoms of acute pancreatitis (e.g., severe abdominal pain with or without nausea, vomiting) occur.¹

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹

  
  


• 
  

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription (e.g., glyburide, levothyroxine, oral contraceptives) and OTC (e.g., vitamins) drugs, as well as any concomitant illnesses (e.g., stomach or intestinal disease, including gastroparesis, abnormal contractions of the digestive system, or major GI surgery; vitamin A, D, E, or K deficiencies; difficulty swallowing).^{1 12}

  
  


• 
  

  Importance of informing patients of other important precautionary information.¹ (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Colesevelam Hydrochloride

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Tablets	625 mg	WelChol	Daiichi Sankyo

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Welchol 625MG Tablets (SANKYO): 60/$86.39 or 180/$235.16

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions December 2009. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

References

1. Daiichi-Sankyo Inc. WelChol (colesevelam hydrochloride) tablets prescribing information. Parsippany, NJ; 2008 Jan.

2. Anon. Colesevelam (WelChol) for hypercholesterolemia. Med Lett Drugs Ther. 2000; 42:102-4. [PubMed 11056044]

3. Davidson MH, Dillon MA, Gordon B et al. Colesevelam hydrochloride (cholestagel). Arch Intern Med. 1999; 159:1893-900. [IDIS 433533] [PubMed 10493319]

4. Rosenbaum DP, Petersen JS, Ducharme S et al. Absorption, distribution and excretion of GT31-104, a novel bile acid sequestrant, in rats and dogs after acute and subchronic administration. J Pharm Sci. 1997; 86:591-5. [PubMed 9145384]

5. Davidson MH, Dicklin MR, Maki KC et al. Colesevelam hydrochloride: a non-absorbed, polymeric cholesterol-lowering agent. Exp Opin Invest Drugs. 2000; 9:2663-71.

6. Insull W, Toth P, Mullican W et al. Cholestagel, a novel, highly potent, polymeric bile acid sequestrant significantly lowers LDL cholesterol. J Am Coll Cardiol. 2000; 35(suppl A): 258A.

7. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA. 1993;269:3015-23.

8. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Bethesda, MD: National Institutes of Health. (NIH publication No. 01-3670.)

9. Sankyo Pharmaceuticals, Parsippany, NJ: Personal communication.

10. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Adult Treatment Panel III Report. From AHA web site.

12. Daiichi-Sankyo Inc. Important information about Welchol. Parsippany, NJ; 2008. Available from website. Accessed 2008 May 30.

13. Fonseca VA, Rosenstock J, Wang AC et al. Colesevelam HCl improves glycemic control and reduces LDL-cholesterol in patients with type 2 diabetes inadequately controlled on sulfonylurea-based therapy. Diabetes Care. 2008 May 5 (Epub ahead of print). DOI: 10.2337/dc08-0283.

14. Bays HE, Goldberg RB. The 'forgotten' bile acid sequestrants: is now a good time to remember?. Am J Ther. 2007 Nov-Dec; 14:567-80.

15. Grundy SM, Cleeman JI, Bairey Merz CN et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004; 110: 227-39. [PubMed 15249516]

More WelChol resources

• WelChol Side Effects (in more detail)
• WelChol Use in Pregnancy & Breastfeeding
• Drug Images
• WelChol Drug Interactions
• WelChol Support Group
• 19 Reviews for WelChol - Add your own review/rating

• Welchol Prescribing Information (FDA)


• Welchol Concise Consumer Information (Cerner Multum)


• Welchol Advanced Consumer (Micromedex) - Includes Dosage Information


• Welchol MedFacts Consumer Leaflet (Wolters Kluwer)

Compare WelChol with other medications

• Diabetes, Type 2
• Diarrhea, Chronic
• High Cholesterol
• Hyperlipoproteinemia
• Hyperlipoproteinemia Type IIa, Elevated LDL

Water for Injection

Dosage Form: injection

Water for Injection Description

Sterile Water for Injection, USP, is sterile, nonpyrogenic, distilled water in a single dose container for intravenous administration after addition of a suitable solute. It may also be used as a dispensing container for diluent use. No antimicrobial or other substance has been added. The pH is 5.5 (5.0 to 7.0). The osmolarity is 0.

The VIAFLEX plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146 Plastic). The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.

Water for Injection - Clinical Pharmacology

Sterile Water for Injection, USP is used for fluid replacement only after suitable additives are introduced to approximate isotonicity and to serve as a vehicle for suitable medications.

Indications and Usage for Water for Injection

Sterile Water for Injection, USP is indicated in the aseptic preparation of parenteral solutions.

Contraindications

Sterile Water for Injection, USP is a hemolytic agent due to its hypotonicity. Therefore, it is contraindicated for intravenous administration without additives.

Warnings

Do not use for intravenous injection unless adjusted to approximate isotonicity with a suitable solute.

Precautions

Do not administer unless solution is clear and seal is intact.

Adverse Reactions

The administration of a suitable admixture of prescribed additives may be associated with adverse reactions because of the solution or the technique of administration including febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation, and hypervolemia.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures, and save the remainder of the fluid for examination if deemed necessary.

Water for Injection Dosage and Administration

Following suitable admixture of prescribed additives, the dosage is usually dependent upon the age, weight and clinical condition of the patient as well as laboratory determinations. See directions accompanying additive drug.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Injections in VIAFLEX plastic containers are intended for intravenous administration using sterile equipment.

Additives may be incompatible. Complete information is not available. Those additives known to be incompatible should not be used. Consult with pharmacist, if available. If, in the informed judgment of the physician, it is deemed advisable to introduce additives, use aseptic technique. Do not store an unused portion of Sterile Water for Injection, USP. Mix thoroughly when additives have been introduced. Do not store solutions containing additives.

How is Water for Injection Supplied

Sterile Water for Injection, USP is supplied in VIAFLEX plastic containers as follows:

1000 mL

2B0304

NDC 0338-0013-04

Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. It is recommended the product be stored at room temperature (25°C); brief exposure up to 40°C does not adversely affect the product.

DIRECTIONS FOR USE OF VIAFLEX PLASTIC CONTAINER

Warning: Do not use plastic containers in series connections. Such use could result in air embolism due to residual air being drawn from the primary container before administration of the fluid from the secondary container is completed.

To Open

Tear overwrap down side at slit and remove solution container. Some opacity of the plastic due to moisture absorption during the sterilization process may be observed. This is normal and does not affect the solution quality or safety. The opacity will diminish gradually. Check for minute leaks by squeezing inner bag firmly. If leaks are found, discard solution as sterility may be impaired. See following directions.

Preparation for Administration After Rendering Isotonic

1. Suspend container from eyelet support.

2. Remove plastic protector from outlet port at bottom of container.

3. Attach administration set. Refer to complete directions accompanying set.

Warning: Additives may be incompatible.

To add medication before administration

1. Prepare medication site.

2. Using syringe with 19 to 22 gauge needle, puncture resealable medication port and inject.

3. Mix solution and medication thoroughly. For high density medication such as potassium chloride, squeeze ports while ports are upright and mix thoroughly.

To add medication during administration

1. Close clamp on the set.

2. Prepare medication site.

3. Using syringe with 19 to 22 gauge needle, puncture resealable medication port and inject.

4. Remove container from IV pole and/or turn to an upright position.

5. Evacuate both ports by squeezing them while container is in the upright position.

6. Mix solution and medication thoroughly.

7. Return container to in use position and continue administration.

Baxter Healthcare Corporation

Deerfield, IL 60015 USA

7-19-31-347 Rev. September 2002

BAXTER, VIAFLEX, and PL 146 are trademarks of Baxter International Inc.

STERILE WATER  water  injection, solution

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0338-0013 Route of Administration INTRAVENOUS DEA Schedule

INGREDIENTS Name (Active Moiety) Type Strength Water (water) Active 100 MILLILITER  In 100 MILLILITER

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0338-0013-04 1000 mL (MILLILITER) In 1 BAG None

Revised: 09/2006Baxter Healthcare Corporation

More Water for Injection resources

• Water for Injection Support Group
• 0 Reviews · Be the first to review/rate this drug

Water PIK Fluoride

Generic Name: sodium fluoride

Dosage Form: aerosol, foam
Water PIK Fluoride FOAM MINT Indications: For the topical application of fluoride to aid in the

protection against dental caries.

Contraindications: This product should not be used with

individuals with known sensitivities to fluoride.

Directions for Use:

1. Remove cap from can.

2. The first time you dispense from a new can, gently lift upward

on the nozzle to break the protective shipping tab (Fig. 1).

3. Shake can vigorously for at least 10 seconds before each use.

4. Hold can completely upside down to dispense (Fig. 2).

5. Point can towards applicator tray and slowly press the nozzle

to fill tray. Use one press per arch, as foam will expand

slightly to fill the tray.

6. For best results, dry teeth prior to application.

7. Insert the filled tray and have the patient bite down lightly,

with a chewing motion to ensure interproximal coverage.

8. Leave tray(s) in contact with teeth for 1 to 4 minutes.

9. Use a saliva ejector during treatment to minimize ingestion

of product.

10. Remove tray(s) and have patient expectorate.

11. Instruct patient not to eat, drink, or rinse for at least 30

minutes after application.
Contains:

1.23% Fluoride ion from sodium fluoride in a proprietary

acidulated phosphate flavored foam base. Does not contain

chlorofluorocarbon propellant.

Sweetened with Xylitol (sucralose). Does not contain Aspartame

or Saccharin. Gluten free.
Precautions:

Use only as directed.

For dental use only. U.S. Federal Law prohibits dispensing

without prescription.

Not for unsupervised home use. Safety and efficacy in patients

under the age of 3 has not been established. Repeated use of

APF formulations in patients with porcelain or composite

restorations should be avoided due to the possibility of etching

the restoration surface. Warning:

Do not swallow.

Keep out of reach of children.

Avoid spraying toward open flame.

Contents under pressure.

Do not puncture or incinerate. WATERPIK

Ultra Control

Fluoride Foam

MINT


Precise foaming action

Sweetened with Xylitol

Gluten free


*Acidulated Phosphate Fluoride

1.23% Fluoride Ion (pH 3.5)


For professional use only.

Store at room temperature

between 55°–80°F.

Shake well before each use.


To obtain a MSDS sheet, please

call Water Pik, Inc. customer

service at 1-800-525-2020.

Made in the U.S.A.

Distributed by:

Water Pik, Inc.

1730 E. Prospect Road

Fort Collins, CO 80553-0001

1-800-525-2020

www.waterpik.com

Waterpik® (stylized) is a

trademark of Water Pik, Inc.

registered Canada, EU, Japan,

Mexico, Switzerland, and the

United States.

©2011 Water Pik, Inc.

Water Pik Item Number:

20014143

FN 20014519-F AA

373485

FLUORIDE  MINT sodium fluoride  aerosol, foam

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 75905-003 Route of Administration DENTAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength SODIUM FLUORIDE (FLUORIDE ION) FLUORIDE ION 1.23 g  in 100 g

Inactive Ingredients Ingredient Name Strength WATER   SUCRALOSE   XYLITOL   SODIUM PHOSPHATE, MONOBASIC, MONOHYDRATE   BETAINE   POLOXAMER 407

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 75905-003-14 125 g In 1 CAN None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved drug other		03/20/2011

Labeler - WATER PIK, INC. (001804074)

Registrant - WATER PIK, INC. (001804074)

Establishment
Name	Address	ID/FEI	Operations
Medical Products Laboratories, Inc.		002290302	manufacture, analysis

Revised: 07/2011WATER PIK, INC.

Wal-itin

Generic Name: loratadine (lor AT a deen)

Brand Names: Alavert, Alavert Allergy, Claritin, Claritin 24 Hour Allergy, Claritin Hives Relief, Claritin Liqui-Gels, Claritin Reditab, Clear-Atadine, Clear-Atadine Children's, Dimetapp ND, Loratadine Reditab, ohm Allergy Relief, Tavist ND, Wal-itin

What is Wal-itin (loratadine)?

Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Loratadine is used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose. It is also used to treat skin hives and itching in people with chronic skin reactions.

Loratadine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Wal-itin (loratadine)?

You should not take this medication if you are allergic to loratadine or to desloratadine (Clarinex).

Ask a doctor or pharmacist before taking this medicine if you have liver or kidney disease.

Do not give this medication to a child younger than 6 years old without the advice of a doctor.

Loratadine disintegrating tablets (Claritin Reditab) may contain phenylalanine. Talk to your doctor before using this form of loratadine if you have phenylketonuria (PKU).

What should I discuss with my healthcare provider before taking Wal-itin (loratadine)?

You should not take this medication if you are allergic to loratadine or to desloratadine (Clarinex).

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• kidney disease; or


• liver disease.

FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Loratadine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Loratadine disintegrating tablets (Claritin Reditab, Alavert) may contain phenylalanine. Talk to your doctor before using this form of loratadine if you have phenylketonuria (PKU).

Do not give this medication to a child younger than 6 years old without the advice of a doctor.

How should I take Wal-itin (loratadine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Loratadine is usually taken once per day. Follow your doctor's instructions.

Do not crush, chew, or break the regular loratadine tablet. Swallow the pill whole.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

To take loratadine orally disintegrating tablet (Claritin RediTab, Alavert):

• 
  

  Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

  
  


• 
  

  Using dry hands, remove the tablet and place it on your tongue. It will begin to dissolve right away.

  
  


• 
  

  Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

  
  


• 
  

  Swallow several times as the tablet dissolves. If desired, you may drink water to help swallow the dissolved tablet.

  
  

Call your doctor if your symptoms do not improve.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, drowsiness, and fast or pounding heartbeat.

What should I avoid while taking Wal-itin (loratadine)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Wal-itin (loratadine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  fast or uneven heart rate;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  jaundice (yellowing of your skin or eyes); or

  
  


• 
  

  seizures (convulsions).

  
  

Less serious side effects may include:

• 
  

  headache;

  
  


• 
  

  nervousness;

  
  


• 
  

  feeling tired or drowsy;

  
  


• 
  

  stomach pain, diarrhea;

  
  


• 
  

  dry mouth, sore throat hoarseness;

  
  


• 
  

  eye redness, blurred vision;

  
  


• 
  

  nosebleed; or

  
  


• 
  

  skin rash.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Wal-itin (loratadine)?

There may be other drugs that can interact with loratadine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Wal-itin resources

• Wal-itin Side Effects (in more detail)
• Wal-itin Use in Pregnancy & Breastfeeding
• Wal-itin Drug Interactions
• Wal-itin Support Group
• 0 Reviews for Wal-itin - Add your own review/rating

• Loratadine Monograph (AHFS DI)


• Loratadine Professional Patient Advice (Wolters Kluwer)


• Alavert Syrup MedFacts Consumer Leaflet (Wolters Kluwer)


• Alavert Prescribing Information (FDA)


• Claritin Consumer Overview


• Claritin Prescribing Information (FDA)


• Claritin 24 Hour Allergy MedFacts Consumer Leaflet (Wolters Kluwer)


• Claritin Liqui-Gels MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Wal-itin with other medications

• Hay Fever
• Urticaria

Where can I get more information?

• Your pharmacist can provide more information about loratadine.

See also: Wal-itin side effects (in more detail)

Welchol

Generic Name: colesevelam (KOE le SEV e lam)

Brand Names: Welchol

What is Welchol (colesevelam)?

Colesevelam is a cholesterol-lowering drug.

Colesevelam lowers "bad" cholesterol in the blood, which is also called LDL (low-density lipoprotein) cholesterol. Lowering your LDL cholesterol may reduce your risk of hardened arteries, which can lead to heart attacks, stroke, and circulation problems.

Colesevelam is sometimes used together with another cholesterol-lowering medication such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor).

Colesevelam is also used to improve glycemic control in people with type 2 diabetes. This medication is not for treating type 1 diabetes.

Do not take colesevelam if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Colesevelam may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Welchol (colesevelam)?

Do not take this medication if you are allergic to colesevelam, or if you have a bowel obstruction or if you have ever had pancreatitis caused by high triglycerides.

Before taking colesevelam, tell your doctor if you have trouble swallowing, or if you have a history of major stomach or bowel surgery, a vitamin deficiency, or a blockage in your stomach or intestines.

Avoid eating foods that are high in fat or cholesterol. Colesevelam will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Do not take any other medications within 4 hours before or after you take colesevelam. Colesevelam can make it harder for your body to absorb certain other medications. Stop using colesevelam and call your doctor at once if you have severe constipation or stomach pain.

Colesevelam is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Do not change the dose or timing of any other cholesterol or diabetes medications without your doctor's advice.

What should I discuss with my health care provider before taking Welchol (colesevelam)?

You should not use colesevelam if you are allergic to it, or if you have a bowel obstruction or if you have ever had pancreatitis caused by high triglycerides.

To make sure you can safely take colesevelam, tell your doctor if you have any of these other conditions:

• 
  

  trouble swallowing;

  
  


• 
  

  a stomach, intestinal, or digestive disorder;

  
  


• 
  

  a history of major stomach or bowel surgery; or

  
  


• 
  

  if you have a vitamin A, D, E, or K deficiency.

  
  

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking colesevelam can make it harder for your body to absorb certain vitamins. These vitamins are important if you are nursing a baby. Do not take colesevelam without telling your doctor if you are breast-feeding a baby. Colesevelam should not be given to a child younger than 10 years old, or to a girl who has not yet started having menstrual periods.

The liquid form may contain phenylalanine. Talk to your doctor before using this form of colesevelam if you have phenylketonuria (PKU).

How should I take Welchol (colesevelam)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take this medicine with a meal and a full glass of water or other liquid.

You may have to take several tablets at a time each time you take colesevelam. Follow your doctor's instructions. Tell your doctor if you have trouble swallowing the tablet whole.

To use the colesevelam powder, empty 1 packet into 4 to 8 ounces of water, fruit juice, or a soft drink. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

Colesevelam is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Do not change the dose or timing of any other cholesterol or diabetes medications without your doctor's advice.

To be sure this medication is helping your condition, your blood may need to be tested often. Visit your doctor regularly.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember (be sure to take the medicine with food and a full glass of water). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Because colesevelam is not absorbed into the bloodstream, an overdose of this medication is not expected to produce life-threatening symptoms. It is possible that an overdose may cause severe constipation.

What should I avoid while taking Welchol (colesevelam)?

Avoid eating foods that are high in fat or cholesterol. Colesevelam will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Do not take any other medications within 4 hours before or after you take colesevelam. Colesevelam can make it harder for your body to absorb certain other medications.

Welchol (colesevelam) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using colesevelam and call your doctor at once if you have severe constipation or stomach pain.

Less serious side effects may include:

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  mild constipation;

  
  


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  nausea, vomiting, upset stomach, gas, indigestion;

  
  


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  feeling weak or tired;

  
  


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  headache;

  
  


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  muscle pain; or

  
  


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  runny nose, sore throat, flu symptoms.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Welchol (colesevelam)?

Do not take your other medications at the same time you take colesevelam, unless your doctor has told you to. Colesevelam can make it harder for your body to absorb certain other medications.

Tell your doctor about all other medicines you use, especially:

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  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


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  phenytoin (Dilantin);

  
  


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  a blood thinner such as warfarin (Coumadin, Jantoven);

  
  


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  glyburide (DiaBeta, Glynase Presab, Micronase, Glucovance);

  
  


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  thyroid hormone replacement; or

  
  


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  birth control pills.

  
  

This list is not complete and other drugs may interact with colesevelam. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Welchol resources

• Welchol Side Effects (in more detail)
• Welchol Use in Pregnancy & Breastfeeding
• Drug Images
• Welchol Drug Interactions
• Welchol Support Group
• 19 Reviews for Welchol - Add your own review/rating

• Welchol Prescribing Information (FDA)


• Welchol Advanced Consumer (Micromedex) - Includes Dosage Information


• Welchol MedFacts Consumer Leaflet (Wolters Kluwer)


• WelChol Monograph (AHFS DI)

Compare Welchol with other medications

• Diabetes, Type 2
• Diarrhea, Chronic
• High Cholesterol
• Hyperlipoproteinemia
• Hyperlipoproteinemia Type IIa, Elevated LDL

Where can I get more information?

• Your pharmacist can provide more information about colesevelam.

See also: Welchol side effects (in more detail)